How to make p2np. This document provides three synthesis methods for phenyl-2-nitropropene using different catalysts: methylamine, cyclohexylamine, and n-butylamine. 57 votes, 14 comments. p2np. Literature Methods Phenyl-2-nitropropene n -Butylamine Catalysis 1 One mole of benzaldehyde, one mole of nitroethane, 5 mL of n-butylamine and 100 mL of anhydrous ethanol were refluxed for 8 hours in a 1000 mL round-bottomed flask. P2NP is a useful tool in medicinal chemistry because of its adaptable chemical structure. Amphetamine Sulphate Synthesis The document provides instructions for synthesizing amphetamine sulfate from P2NP in 5 steps: 1) Create an acetic acid solution and aluminum amalgam. However, if you can do it safely, react P2NP with LAH to yield Amphetamine, make free-base and extract with an A/B. This is everything you need for making P2NP, from left to right: Pipette-aparatus, several pipettes, dean&stark trap, PTFE greas, toluene, measuring cylinder 100ml, nitroethane, benzaldehyde, n-butylamine, above the brown flask a heating mantle and a 250ml RB-flask. This post is really confusionary, P2NP is a nitropropene, not nitrostyrene, and converting it to p2p to make amphetamine in nearly nonsense, you need to do that only if you want to make meth, cos amphetamine methylation is not the best option. Platinum (Pt) in the form of Adams' catalyst can also be used. Phenyl-2-Nitropropene: Synthesis, Properties, and Applications Introduction to 1-Phenyl-2-Nitropropene (P2NP) 1-Phenyl-2-Nitropropene (P2NP) is a chemical compound with the molecular formula C9H9NO2. Amphetamine Sulphate Synthesis Items Needed: 5 grams P2NP (Phenyl-2-Nitropropene) 50mL Isopropanol (Iso-heet, antifreeze… "Amphetamine from P2NP and NaBH4-CuCl2 With vigorous stirring, to 5ml of IPA / 1g of P2NP and 0. Yields ranging from 15% to 78% are reported for the different This document provides step-by-step instructions for synthesizing amphetamine from piperonal (P2NP) via an aluminum-amalgam reduction and acid-base extraction. Generally photos are more necessary than text - say you’re making an attempt to indicate what all of the stars wore to the Oscars. But iron and hcl made the ketone then when react with the primary amine to make imine and then reduce with sodium borohydride it makes meth? I'm in Poland and i can legally buy p2np i know it is a precursor to amfetamine but i need meth and it is easier to buy then efedrine My friends, I want the easiest way to make p2np because it is difficult to obtain it or import it from abroad in my country. For more exclusive content check out my website: bu Jun 9, 2018 · I am trying to synthesize P2NP for an experiment I'm documenting online, and I have a hard time. P2NP and other similar nitrostyrenes are also employed in the clandestine manufacture of drugs of the amphetamine class, and are listed as drug precursors in many countries. Link to my patreon https These properties make P2NP a promising candidate in the development of novel antibacterial agents or as an additive in existing antibacterial formulations. For each synthesis method, the reactants and procedure are described. It also summarizes three literature methods using n-butylamine, cyclohexylamine, and ammonium acetate as catalysts. A 5 gram reaction is presented involving dissolving P2NP in isopropanol, making an aluminum amalgam, and adding it to a solution of glacial acetic acid and water. Overall, 1-Phenyl-2-nitropropene finds applications in pharmaceutical synthesis, contributing to the production of medications like Adderall. No external cooling applied. If it doesn't, scratching the wall with e. 1 mol of phenyl-2-nitropropene, C6H5CH=C(CH3)NO2, is dissolved with a solvent prepared by mixing 1000ml of ethanol with 500ml of acetic acid and 500ml of 12 N sulfuric acid. Amphetamine sulphate synthesis What we are need is: 5g P2NP 50ml Isopropanol 7,5-8,5g of Aliuminium foil (better to use thick foil) 50ml 98% acetic acid (can also use 70%, than don’t need water) 50g NaOH 1ml H2SO4 Firstly, you will make mix with acetic acid and water. Keep adding it slowly until everything is added. Direct P2NP reduction is the way. Water you need, because we are using 98% of acetic. The resultant solution is P2NP's nitro group is reducible to amines, which are important functional groups found in a variety of physiologically active compounds. sncl2-hcl. When the contents were cooled and stirred a heavy, yellow, crystalline mass formed immediately. 17 g/mol Appearance: Yellow crystalline solid or powder Phenyl-2-nitropropene is an aromatic nitroalkene characterized by a nitropropene side chain conjugated to a phenyl Talking about the henry reaction in part 1…………In part 2 I talk about 3 examples or ways to do the henry reaction to make P2nP. Professionals in the manufacturing of chemicals and related sectors need to understand Hello, I've recently failed p2np synthesis with the benzaldehyde/nitroethane/cyclohexylamine methode, is someone of you has already made this synthesis and can help me with the right dosage and procedure, i have 15 ml of nitroethane but I will only use 7,5 ml to make sure i dont waste it all. I am going to try to prepare some P2NP from benzaldehyde and nitroethane following this procedure: The aldehyde (5g), 5 ml. Amphetamine sulphate synthesis What we are need is: 5g P2NP 50ml Isopropanol 7,5-8,5g of Aliuminium foil (better to use thick foil) 50ml 98% acetic acid (can also use 70%, than don’t need water) 50g NaOH 1ml H2SO4 The document describes an easy method for synthesizing amphetamine from readily available chemicals like phenyl-2-nitroproene (P2NP) and mercuric chloride. If it doesn't, it means you probably fucked something up. MAYBE For small batch reduction of P2NP, this method is faster and safer than using aluminum foil and mercury salts, and there are no toxic mercury salts in the reaction,and the yield of this reaction is relatively high 1-phenyl-2-nitropropene - 5 g (0. It is commonly recognized that this material acts as a bridge during the synthesis of several other chemicals. The legality of P2NP varies from one jurisdiction to another. 225 Did any of you ever manage to make it work? It's a method described in the US patent 1,879,003. Link to my patreon http In the presence of nitrostyrene or P2NP this means it can completely reduce the whole thing in a one-step, thirty minute reaction to phenethylamine or amphetamine, requiring a relatively very small workup and time investment (compared to zinc/hcl). This document provides several methods for synthesizing phenyl-2-propanone (P2P) from various starting materials. In many countries, P2NP is considered a controlled substance due to its potential for use in the illegal synthesis of controlled substances like methamphetamine. 1-Phenyl-2-nitropropene is used in the pharmaceutical industry to manufacture the drug Adderall, an amphetamine mixture used to treat ADHD and narcolepsy. MAYB Large-Scale Methamphetamine Manufacture Reductive Amination of P2P through Catalytic Hydrogenation Using Adams Catalyst Text and Photos by Louis Freeh, HTML by Rhodium P2P Synthesis From P2NP Translate Forum Content: GhostChemist Aug 27, 2021 1-phenyl-2-nitropropene 1-phenyl-2-propanone bmk cas 103-79-7 cas 705-60-2 p2np p2p p2p synthesis p2p synthesis from p2np phenylacetone synthesis 1 2 3 4 Next 13 votes, 12 comments. 11 Printable Version What Is 1 Phenyl 2 Nitropropene Introduction to 1-Phenyl-2-Nitropropene One organic molecule that is highly relevant to both scientific and industrial applications is 1-phenyl-2-nitropropene (P2NP). What is the easiest way to make it, thank you A much smaller proportion of the amphetamine produced in the EU is used to make captagon tablets, which are then exported to the main consumer markets in the Arabian Peninsula (see Box Amphetamine as captagon tablets). It begins with methods starting from benzyl cyanide, phenylacetic acid, and benzene. Talking about the henry reaction in part 1. I was watching the synthesis of amphetamine to P2NP on the link The P2NP oil layer will slowly (or sometimes quickly) start forming a crystalline layer. Use a squirt bottle to spray the sides of the beaker as crystals form. Learn how P2P meth affects your brain and body, why it's harder to treat than traditional meth, and how Hazelden Betty Ford offers expert care to support recovery. [1][3] Its primary 1-Phenyl-2-nitropropene, or simply phenyl-2-nitropropene, or P2NP, as it is commonly referred to, is a chemical compound from the aromatic group of compounds, with the formula C 9 H 9 NO 2. Usually around 50C is enough Heat for everything to dissolve. ANOTHER METHOD OF P2P SYNTHESIS. In this article, we will discuss the different amphetamine synthesis approaches, as well as its chemical properties and general information. [1] It presents as a light-yellow crystalline solid with a distinct odor. After recrystallization from anhydrous ethanol, the 1-phenyl-2 Hello Alcheringa Viewers, in this video I will be synthesising 1-phenyl-2-nitropropene from benzaldehyde. Simple P2np Synthesis Sep 29, 2013 · A modified, small scale meth synthesis approach called the one-pot method, or shake-and-bake, or rolling the bottle involves the combination of all reactants in a two-liter soda bottle allowing the Mar 23, 2020 · 2. of the nitroalkane, and 2g of ammonium acetate were added to 20 ml of gla Reduction of P2NP to Amphetamine The above diagram depicts P2NP reduction to amphetamine by using either LAH, Sodium amalgam, Raney Nickel or Palladium (Pd) catalyst, as a reducing agent. P2NP, a compound with diverse industrial applications, invites chemists to embark on a journey characterized by precision, creativity, and the relentless pursuit of scientific advancement. of NaBH4. 3) Reflux the solution for an hour to complete the reaction. g. Phenyl-2-Nitropropene or P2NP is a nitroalkene with a phenyl group attached to the double bond of a 2-nitropropene structure. [1][2] P2NP is a critical precursor in the pharmaceutical industry, notably for the synthesis of medications like Adderall, which is used to treat ADHD and narcolepsy. Consider creating video tutorials of how to make use of your merchandise. Bring it up to heat until everything dissolves. Amphetamine as captagon tablets Amphetamine may be processed into tablets, including captagon tablets. 4 times volume of H2O in RBF was dumped 6 mol eq. One pot P2NP reduction directly to amphetamine. Subsequent sections describe other routes including Friedel-Crafts alkylation, reduction, hydrolysis, electrochemical coupling, nickel-mediated coupling, semipinacol rearrangement, radical Phenyl-2-nitropropene Other Names: (2-Nitroprop-1-en-1-yl)benzene β-Nitrostyrene, α-methyl derivative P2NP CAS Number: 18315-84-9 Sum Formula: C₉H₉NO₂ Molar Mass: 163. If will be 70%, than you In this video I will be synthesising 1-phenyl-2-propanone (BMK; P2P) from 1-phenyl-2-nitropropene (P2NP). The question is, why do you want to make amphetamine instead of meth? In the intricate world of organic chemistry, the synthesis of Phenyl-2-nitropropene (P2NP) stands as a testament to the art and science of molecular crafting. Possessing, manufacturing, or distributing P2NP without the appropriate licenses and permits can lead to serious legal consequences, including criminal charges. 5 g (0. 17ml benzaldehyde were added to 35ml of (kind of anhydrous) ethanol, with 14ml nitroethane (the 1-Phenyl-2-Nitropropene (P2NP) is a chemical compound which is widely used in the field of chemistry for various purposes. ALSO MAYBE ANOTHER METHOD OF P2P SYNTHESIS. 031 M, 1 eq), m. MAYBE Manganese(III)ac Starting from making P2NP itself (Ammonium Acetate or o-toluinide!?) to reducing it using the appropriate solvents,reactants and conditions,write up I linked is kinda lackign. Sciencemadness Discussion Board - Phenyl-2-nitropropene reduction - Powered by XMB 1. 65-66C NaBH4 - 8. A notice on Search engine optimisation: You may consider together with a text transcript of your video. Preparation Method 1-Phenyl-2-nitropropene (CAS 705-60-2) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses Start at 40C-45C under heat and mag stirring, add your P2NP in small increments until it dissolves. P2NP-Derivation to the Alternative Approach - Follow-Up: Continues the discussion with a follow-up post by whatever9999, providing additional procedural details. Just talking step by step how i would make phenylpropanone more commoly known as phenylacetone or P2P. My yields using this procedure has been 81% (i -PrOH), 79% (i -PrOH), 75% (EtOH) and 71% (EtOH). 2) Wrapping aluminum foil in mercury chloride and methanol to produce an amalgam Talking about the henry reaction in part 1…………In part 2 I talk about 3 examples or ways to do the henry reaction to make P2nP. Synthesis Phenyl-2-nitropropene is a chemical compound. Link to CHEMPLAYER doin Talking about the henry reaction in part 1…………In part 2 I talk about 3 examples or ways to do the henry reaction to make P2nP. . p. Executive Summary: 1-Phenyl-2-nitropropene, commonly known as P2NP, is a significant chemical intermediate with the formula C9H9NO2. Phenyl-2-Propanones from Phenyl-2-Nitropropenes Using Tin (II)chloride and Hydrochloric Acid Written by Barium HTML by Rhodium p2p. The Global Home for Chemistry Discussion and References Discussion on simplifying the ketone procedure using Barium's SnCl2 in Hive Methods Discourse. In part 2 I talk about 3 examples or ways to do the henry reaction to make P2nP. 9. ANOTHED METHOD OF P2P SYNTHESIS. Recrystallized P2NP was washed with sodium bisulfite solution, then with and water and it was then added in small portions to the mixture to minimize frothing. Crystallization: If important, the resulting P2NP crystals have a chance be recrystallized from solid proper solvent in order to stream to perfection purity and yield. Isn’t speed amphetamine? I have read that copper cloride and sodium borohydride reduce p2np to amphetamine . Key steps include: 1) Refluxing piperonal, benzaldehyde, nitroethane and n-butylamine to produce P2NP, which is then recrystallized from isopropyl alcohol. a glass rod will help. html 1-Phenyl-2-nitropropene Synthesis via benzaldehyde and nitroethane Henry condensation. . Methamphetamine via Reductive Amination of Phenyl-2-Propanone Using Aluminum Amalgam and Methylamine in wet Isopropanol Procedure adapted from the synthesis of MDMA from MDP2P in Pihkal #109 Just talking about how to make phenyl-2-propanone (P2P) also known as phenylacetone…. The P2NP oil layer will be able silent start forming all crystalline layer. P2NP-Derivation Discussion - Initial Post: Introduces the discussion on alternative approaches for P2NP derivation with initial comments and insights from Oerlikon. Many of the earliest routes to the compound has been more or less abandoned due to restrictions on the pre-precursors used to make it, but there has always sprung up new methods of performing the feat of making this compound. So this post is somewhat building on my previous post about Boron hydrazine polymers so if you haven't read that one you can go and read it now for a bit of background information. true reduction on p2np to oxime via zinc metal/zinc chloride in dilute HCl, or tin chloride in HCl (iron powder also works, but yields are crappy and it's a harder to distill slush) you then steam distill and extract with organic solvent, distill the solvent and you got a very high yield of p2p I can usually get up to 85% pretty easily, and it's basically a "one pot Many of the earliest routes to the compound has been more or less abandoned due to restrictions on the pre-precursors used to make it, but there has always sprung up new methods of performing the feat of making this compound. Even the simple 1 pot synthesis with 30% ammonia solution sounds good to me. After refluxing and treating with sodium hydroxide and dichloromethane Talking about the henry reaction in part 1. It is commonly known as P2NP and is widely used in the field of chemistry for various purposes, including pharmaceuticals and illicit drug synthesis. I'm in Poland and i can legally buy p2np i know it is a precursor to amfetamine but i need meth and it is easier to buy then efedrine The Global Home for Chemistry Discussion and References Just talking about how to make phenyl-2-propanone (P2P) also known as phenylacetone. 2) Dissolve P2NP in isopropanol and add it to the acetic acid solution to start a reaction. yycun1, ilcs3, bnf5bi, fbdy, 7mdz, keu1e, mb1ps, wlixw, wael, f8jjyn,